Environmental Health Perspectives, vol. 12, pp 157-74, 2009. 213, pp 15-20, 2012. Human Reproduction, vol. August 13, 2014. FOUND IN: Color cosmetics, fragranced lotions, body washes and hair care products, nail polish and treatment, WHAT TO LOOK FOR ON THE LABEL:  phthalate, DEP, DBP, DEHP and fragrance, WHAT ARE PHTHALATES? Cancer: The National Toxicology Program and U.S. Environmental Protection Agency report that DEHP is reasonably to be anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity of animal studies. [21] Hauser R, et al., DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Phthalates (US: / ˈ θ æ l eɪ t s /, UK: / ˈ θ ɑː l eɪ t s /), or phthalate esters, are esters of phthalic acid.They are mainly used as plasticizers, i.e., substances added to plastics to increase their flexibility, transparency, durability, and longevity. [36],[37]  Both DEHP and DBP appear to have weak estrogenic effects. [18] Main KM, et al., Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. [10] Centers for Disease Control and Prevention (CDC). Available online: https://www.cdc.gov/niosh/npg/npgd0438.html. A review of epidemiological studies. It has been very difficult, however, to determine the minimum level of exposure when these problems arise. [4] Byrdie.14 ‘5 free’ nail polish brands. Because they are in so … The non-profit Environmental Working Group launched the Not Too Pretty campaign to raise awareness about the dangers of phthalates, industrial chemicals that are used as solvents in many cosmetics. Additionally, phthalates are used in personal skin care products for viscosity control and are also used as stabilizers, dispersants, lubricants, binders, emulsifying agents, and suspending agents. List of 146 substances with endocrine disruption classifications prepared in the espert meeting. 30, no. Too many beauty or self-care products contain phthalates that go directly onto your skin and into your pores. Most of the mainstream hair sprays, deodorants, nail polishes and perfumes that millions of people use every day contain these harmful chemicals. [39] Chen FP. Available online: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241863/pdf/ehp0112-000331.pdf August 14, 2014. The female reproductive system may be less sensitive to phthalate exposure than the male reproductive system,[28] although a few studies have found female reproductive effects. [34],[35] DBP has been shown to cause proliferation of breast tumor cells and to make anti-estrogen treatments, such as tamoxifen, less effective against tumors. [29] A study of infertile couples found significantly exposure to DEP among infertile men and higher DEP and DBP exposure among infertile women. Toxicological Science, vol. 68, pp 1995-2003, 2005. [25],[26],[27] [38],[39]  The National Institute of Occupational Safety and Health demonstrates that DEHP can cause liver tumors in animals. Available online: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367843/pdf/ehp0114-000270.pdf. Some are considered safe, and others are considered to pose a potential risk. By Zoe Dubs. GLOSSARY. [25],[26],[27], The female reproductive system may be less sensitive to phthalate exposure than the male reproductive system,[28] although a few studies have found female reproductive effects. Environmental Health Perspectives, vol. International Journal of Occupational Medicine and Environmental Health, vol. Available online: http://www.safecosmetics.org/wp-content/uploads/2015/02/A-Little-Prettier.pdf August 18, 2014. [10], HEALTH CONCERNS: Endocrine disruption, developmental and reproductive toxicity, cancer MORE... August 18, 2014. Available online: http://toxsci.oxfordjournals.org/content/93/1/189.full.pdf+html. Available online: http://humrep.oxfordjournals.org/content/22/3/688.full.pdf+html. Di(2-ethylhexyl) phthalate. Dry … Aging Skin. 3 MOONS is a skincare solution, in which the range of products focuses on effective treatment rather than covering imperfections. & Hanke W., Exposure to phthalates: reproductive outcome and children health. Shown to damage the liver, kidneys, lungs and reproductive systems in animal studies, phthalates can be absorbed through the skin or inhaled. Available online: https://echa.europa.eu/substance-information/-/substanceinfo/100.003.829 August 13, 2014. Available online: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280349/pdf/ehp0113-001056.pdf. [16] Breast Cancer Prevention Partners Glossary of Exposures: https://www.bcpp.org/resource/phthalates/, [17] Swan SH, et al., Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure. Phthalates are in so many products, they are industrial plasticizers aimed to make items more flexible and give them work-ability. Jane Iredale, whose namesake fifteen-year-old skincare and cosmetics company is phthalate- and paraben-free, substitutes natural antioxidants for synthetic preservatives and sponsors events held by Teens for Safe Cosmetics, a branch of the nonprofit environmental organization Search for the Cause. MINERAL OIL. Abstract Available Online: http://www.ncbi.nlm.nih.gov/pubmed/20551087. A Little Prettier. [17] Other research in humans has shown altered hormone levels in baby boys exposed to DEP and DEHP in breast milk. Not Too Pretty: Phthalates, Beauty Products and the FDA. August 18, 2014. Reports on Carcinogens, twelfth edition, 2011: Di(2-ethylhexyl) phthalate Available online: http://ntp.niehs.nih.gov/ntp/roc/twelfth/roc12.pdf August 13, 2014. [18] [4] 2) DEP is widely used in scented products to help the scent linger, although it is rarely found on labels because it is a constituent of the ubiquitous ingredient “fragrance.” A third phthalate, Di-2-ethylhexylphthalate (DEHP) is found in eyelash glue, and is widely used in other consumer products. [31],[32],[33], Cancer: The National Toxicology Program and U.S. Environmental Protection Agency report that DEHP is reasonably to be anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity of animal studies. August 18, 2014. EWG maintains a free online database named "Skin Deep", which list lotions, creams, and polishes that contain phthalates. August 18, 2014. Non-hispanic whites have the lowest levels. [26] Main KM, et al., Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. In the most recent data from the National Biomonitoring Program, the highest levels are found in non-Hispanic blacks, followed by Mexican-Americans. [20]European Chemicals Agency (ECHA). 6, pp 507-14, 2010. In the most recent data from the National Biomonitoring Program, the highest levels are found in non-Hispanic blacks, followed by Mexican-Americans. It also provides information on many other chemical compounds found in products beyond just cosmetics, including sunscreens, baby products, and toothpaste. Diethyl phthalate. July 24, 2008. 67, pp 2025-2035, 2004. [38],[39]  The National Institute of Occupational Safety and Health demonstrates that DEHP can cause liver tumors in animals. Triclosan was all … 1, pp 189-95, 2006. phthalates are also present in cosmetics, nail polish, hair products, skin care products, and some medications. [33] Kang SC. 24, no. Phthalates. August 18, 2014. [6] Our 2008 follow-up testing found that phthalate levels had dropped in some – though not all – of the products tested previously in 2002. [37] Alam MS., et al., Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate. 139, pp 427-37, 2010. Bis(2-ethylhexyl) phthalate. Two are widely used in personal care products: 1) dibutyl phthalate (DBP) is used in nail polish, and is listed by the EU as an endocrine-disrupting compound of high concern. What are Phthalates? [9] While levels of DEP have declined over time, disparities in exposure persist. Toxicology, vol. [11]  In addition, the Endocrine Disruption Exchange (TEDX) includes DEP,[12] DEHP,[13] and DBP[14] as endocrine disruptors. Nail polishes more staying power 24 ] Pant N., et al., Urinary levels of DEP have over. Prevention phthalates in skincare CDC ) Edward J. 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